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Protein basic information

LiverAtlas Protein ID

HuLPr29943

Uniprot ID

PLPP_HUMAN

Uniprot Acc

Q96GD0;Q9UGY2;

Protein name

Pyridoxal phosphate phosphatase

Comment

FUNCTION:Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and Pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.||CATALYTIC ACTIVITY:Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate.||COFACTOR:Divalent ions. Magnesium is the most effective.||SUBUNIT:Homodimer.||TISSUE SPECIFICITY:Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain.||SIMILARITY:Belongs to the HAD-like hydrolase superfamily.

Gene name

pyridoxal (pyridoxine, vitamin B6) phosphatase

Protein sequence

MARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGA PELLERLARAGKAALFVSNNSRRARPELALRFARLGFGG LRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGL RAELRAAGLRLAGDPSAGDGAAPRVRAVLVGYDEHFSFA KLREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSL AAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLM VGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAG QHDLVPHYYVESIADLTEGLED

Database cross reference

RefSeq Protein accession:NP_064711
RefSeq Protein gi:10092677

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-F

GO:0031072;F:heat shock protein binding;IDA:MGI. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0004721;F:phosphoprotein phosphatase activity;IDA:MGI. GO:0033883;F:pyridoxal phosphatase activity;IEA:EC.

GO-P

GO:0071318;P:cellular response to ATP;IDA:MGI.

Pathway

Pathway name

Vitamin_B6_Metabolism