Protein basic information
| LiverAtlas Protein ID |
HuLPr29963 |
|
Uniprot ID |
|
|
Uniprot Acc |
O60486;Q59H25; |
|
Protein name |
Plexin-C1 |
|
Comment |
FUNCTION:Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).||SUBUNIT:Monomer. Homodimer. Interacts with SEMA7A.||INTERACTION:Q8JL80:EVM139 (xeno); NbExp=2; IntAct=EBI-2927384, EBI-2927425; O75326:SEMA7A; NbExp=2; IntAct=EBI-2927384, EBI-1753538;||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (Potential).||TISSUE SPECIFICITY:Detected in heart, brain, lung, spleen and placenta.||PTM:N-glycosylated.||SIMILARITY:Belongs to the plexin family.||SIMILARITY:Contains 1 Sema domain. |
|
Subcellular localization |
Membrane;Single-pass type I membrane protein(Potential). |
|
Gene name |
|
|
Protein sequence
|
MEVSRRKAPPRPPRPAAPLPLLAYLLALAAPGRGADEPVW RSEQAIGAIAASQEDGVFVASGSCLDQLDYSLEHSLSRL YRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPYREGAAG LGGLLLTGWTFDRGACEVRPLGNLSRNSLRNGTEVVSCH PQGSTAGVVYRAGRNNRWYLAVAATYVLPEPETASRCNP AASDHDTAIALKDTEGRSLATQELGRLKLCEGAGSLHFV DAFLWNGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVL FQGQASLDCGHGHPDGRRLLLSSSLVEALDVWAGVFSAA AGEGQERRSPTTTALCLFRMSEIQARAKRVSWDFKTAES HCKEGDQPERVQPIASSTLIHSDLTSVYGTVVMNRTVLF LGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLV PDPVKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTATD PHCGWCHSLQRCTFQGDCVHSENLENWLDISSGAKKCPK IQIIRSSKEKTTVTMVGSFSPRHSKCMVKNVDSSRELCQ NKSQPNRTCTCSIPTRATYKDVSVVNVMFSFGSWNLSDR FNFTNCSSLKECPACVETGCAWCKSARRCIHPFTACDPS DYERNQEQCPVAVEKTSGGGRPKENKGNRTNQALQVFYI KSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTC DKDVIQVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGNC SSVGSLSYIALPHCSLIFPATTWISGGQNITMMGRNFDV IDNLIISHELKGNINVSEYCVATYCGFLAPSLKSSKVRT NVTVKLRVQDTYLDCGTLQYREDPRFTGYRVESEVDTEL EVKIQKENDNFNISKKDIEITLFHGENGQLNCSFENITR NQDLTTILCKIKGIKTASTIANSSKKVRVKLGNLELYVE QESVPSTWYFLIVLPVLLVIVIFAAVGVTRHKSKELSRK QSQQLELLESELRKEIRDGFAELQ |
|
Database cross reference |
RefSeq Protein accession:NP_005752
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005622;C:intracellular;IEA:InterPro. GO:0005886;C:plasma membrane;EXP:Reactome. |
|
GO-F |
GO:0004872;F:receptor activity;IEA:InterPro. GO:0005102;F:receptor binding;TAS:ProtInc. |
|
GO-P |
GO:0007411;P:axon guidance;TAS:Reactome. GO:0007155;P:cell adhesion;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr29963 |
PHOSPHORYLATION |
1466 |
T |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr29963 |
PHOSPHORYLATION |
1350 |
Y |
PhosphoSitePlus |
LTP |
N |
|
