Protein basic information
| LiverAtlas Protein ID |
HuLPr30064 |
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Uniprot ID |
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Uniprot Acc |
Q9BZL4;Q59FK8;Q6ZPD1;Q7L8F7;Q96HW1;Q9H5H5;Q9NT00; |
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Protein name |
Protein phosphatase 1 regulatory subunit 12C |
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Comment |
FUNCTION:Regulates myosin phosphatase activity.||SUBUNIT:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.||SUBCELLULAR LOCATION:Cytoplasm. Note=Along actomyosin filaments and stress fibers.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BZL4-1; Sequence=Displayed; Name=2; IsoId=Q9BZL4-2; Sequence=VSP 052643; Note=No experimental confirmation available; Name=3; IsoId=Q9BZL4-3; Sequence=VSP 030750, VSP 030751; Note=No experimental confirmation available; Name=4; IsoId=Q9BZL4-4; Sequence=VSP 030751; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Ubiquitously expressed. Highly expressed in heart.||PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.||SIMILARITY:Contains 4 ANK repeats.||CAUTION:Although ass |
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Subcellular localization |
Cytoplasm. |
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Gene name |
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Protein sequence
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MSGEDGPAAGPGAAAAAARERRREQLRQWGARAGAEPGPG ERRARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPG AELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVR FLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHG ANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEA AKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAA AKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVED ACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELAR KQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSRE KISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEP RTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGA LGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLA RITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPE SPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRK ARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQ SLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREH RKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRW QRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTE TTLRLAQLKVELERATQRQERFAERPALLELERFERRAL ERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK |
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Database cross reference |
RefSeq Protein accession:NP_060077
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr30064 |
PHOSPHORYLATION |
425 |
T |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr30064 |
PHOSPHORYLATION |
428 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30064 |
PHOSPHORYLATION |
427 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr30064 |
PHOSPHORYLATION |
604 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr30064 |
PHOSPHORYLATION |
509 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr30064 |
PHOSPHORYLATION |
452 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr30064 |
PHOSPHORYLATION |
450 |
S |
PhosphoSitePlus |
HTP |
yes |
|
|
|
HuLPr30064 |
PHOSPHORYLATION |
560 |
T |
PhosphoSitePlus |
LTP |
N |
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