HuLPr30106

Uniprot ID

PPC1B_HUMAN

Uniprot Acc

Q8NEB5;Q3KQX6;Q9BY45;

Protein name

Phosphatidate phosphatase PPAPDC1B

Comment

FUNCTION:Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.||CATALYTIC ACTIVITY:A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.||ENZYME REGULATION:Inhibited by N-ethylmaleimide.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=41 uM for diacylglycerol pyrophosphate; KM=277 uM for phosphatidate; KM=295 uM for lysophosphatidate;||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NEB5-1; Sequence=Displayed; Name=2; IsoId=Q8NEB5-2; Sequence=VSP 025241, VSP 025242; Name=3; IsoId=Q8NEB5-3; Sequence=VSP 040055;||TISSUE SPECIFICITY:Ubiquitous.||SIMILARITY:Belongs to the PA-phosphatase related phosphoesterase family.||SEQUENCE CAUTION:Sequence=AAI06015.2; Type=Erroneous initiation; Note=Transla

Subcellular localization

Membrane;Multi-pass membrane protein(Potential).

Gene name

phosphatidic acid phosphatase type 2 domain containing 1B

Protein sequence

MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPE EMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLK KADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDF FYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAF AGLAFASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAA VIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPL TDAECHKPFQDKLVLSTAQKPGDSYCFDI

Database cross reference

RefSeq Protein accession:NP_001096029
RefSeq Protein gi:156523237

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0008195;F:phosphatidate phosphatase activity;IEA:EC.