Protein basic information
| LiverAtlas Protein ID |
HuLPr30108 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q4J6C6;A7E2X6;D6W5A3;O43163;Q4J6C3;Q4J6C4;Q4ZG39;Q6ZMW7;Q96DW7; |
|
Protein name |
Prolyl endopeptidase-like |
|
Comment |
FUNCTION:Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue.||ENZYME REGULATION:Inhibited by PMSF and Prefabloc, as well as leupeptin at high concentrations. Partially inhibited by TPCK, a chymotrypsin inhibitor, and E64, a cysteine protease inhibitor. Not affected by 4-amidinophenyl-methanesulfonyl fluoride (APMSF), pepstatin or EDTA.||SUBUNIT:Homodimer.||SUBCELLULAR LOCATION:Cytoplasm, cytosol.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4J6C6-1; Sequence=Displayed; Name=2; Synonyms=D; IsoId=Q4J6C6-2; Sequence=VSP 030403; Note=No experimental confirmation available; Name=3; Synonyms=E; IsoId=Q4J6C6-3; Sequence=VSP 030402; Note=No experimental confirmation available; Name=4; IsoId=Q4J6C6-4; Sequence=VSP 030401;||TISSUE SPECIFICITY:Widely expressed. Expressed at higher level in brain, skeletal muscle, heart and kidney.||DISEASE:Defects in PREPL are |
|
Subcellular localization |
Cytoplasm, cytosol. |
|
Gene name |
|
|
Protein sequence
|
MQQKTKLFLQALKYSIPHLGKCMQKQHLNHYNFADHCYNR IKLKKYHLTKCLQNKPKISELARNIPSRSFSCKDLQPVK QENEKPLPENMDAFEKVRTKLETQPQEEYEIINVEVKHG GFVYYQEGCCLVRSKDEEADNDNYEVLFNLEELKLDQPF IDCIRVAPDEKYVAAKIRTEDSEASTCVIIKLSDQPVME ASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATF GDNKRNERFYTEKDPSYFVFLYLTKDSRFLTINIMNKTT SEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYIL TNVGEPTEFKLMRTAADTPAIMNWDLFFTMKRNTKVIDL DMFKDHCVLFLKHSNLLYVNVIGLADDSVRSLKLPPWAC GFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKLFEE TGHEDPITKTSRVLRLEAKSKDGKLVPMTVFHKTDSEDL QKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCH VRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGF SQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFL DVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCP YQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAI AEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQI KFLYEELGLDSTSVFEDLKKYLKF |
|
Database cross reference |
RefSeq Protein accession:NP_001035844
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0004252;F:serine-type endopeptidase activity;IEA:InterPro. |
|
GO-P |
GO:0006508;P:proteolysis;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr30108 |
PHOSPHORYLATION |
479 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
