Protein basic information
| LiverAtlas Protein ID |
HuLPr30155 |
|
Uniprot ID |
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Uniprot Acc |
Q16821;A0AVQ2;A4D0T6;O43476;Q75LN8;Q7KYM8;Q86UI6; |
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Protein name |
Protein phosphatase 1 regulatory subunit 3A |
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Comment |
FUNCTION:Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).||SUBUNIT:Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16821-1; Sequence=Displayed; Name=2; IsoId=Q16821-2; Sequence=VSP 011585, VSP 011586; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay;||TISSUE SPECIFICITY:Skeletal muscle and heart.||DOMAIN:The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphat |
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Subcellular localization |
Membrane;Single-pass membrane protein(By similarity). |
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Gene name |
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Protein sequence
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MEPSEVPSQISKDNFLEVPNLSDSLCEDEEVTFQPGFSPQ PSRRGSDSSEDIYLDTPSSGTRRVSFADSFGFNLVSVKE FDCWELPSASTTFDLGTDIFHTEEYVLAPLFDLPSSKED LMQQLQIQKAILESTESLLGSTSIKGIIRVLNVSFEKLV YVRMSLDDWQTHYDILAEYVPNSCDGETDQFSFKIVLVP PYQKDGSKVEFCIRYETSVGTFWSNNNGTNYTFICQKKE QEPEPVKPWKEVPNRQIKGCLKVKSSKEESSVTSEENNF ENPKNTDTYIPTIICSHEDKEDLEASNRNVKDVNREHDE HNEKELELMINQHLIRTRSTASRDERNTFSTDPVNFPNK AEGLEKKQIHGEICTDLFQRSLSPSSSAESSVKGDFYCN EKYSSGDDCTHQPSEETTSNMGEIKPSLGDTSSDELVQL HTGSKEVLDDNANPAHGNGTVQIPCPSSDQLMAGNLNKK HEGGAKNIEVKDLGCLRRDFHSDTSACLKESTEEGSSKE DYYGNGKDDEEQRIYLGVNEKQRKNFQTILHDQERKMGN PKISVAGIGASNRDLATLLSEHTAIPTRAITADVSHSPR TNLSWEEAVLTPEHHHLTSEGSALGGITGQVCSSRTGNV LRNDYLFQVEEKSGGINSEDQDNSPQHKQSWNVLESQGK SRENKTNITEHIKGQTDCEDVWGKRDNTRSLKATTEELF TCQETVCCELSSLADHGITEKAEAGTAYIIKTTSESTPE SMSAREKAIIAKLPQETARSDRPIEVKETAFDPHEGRND DSHYTLCQRDTVGVIYDNDFEKESRLGICNVRVDEMEKE ETMSMYNPRKTHDREKCGTGNITSVEESSWVITEYQKAT SKLDLQLGMLPTDKTVFSENRDLRQVQELSKKTDSDAIV HSAFNSDTNRAPQNSSPFSKHHTEISVSTNEQAIAVENA VTTMASQPISTKSENICNSTREIQGIEKHPYPESKPEEV SRSSGIVTSGSRKERCIGQIFQTE |
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Database cross reference |
RefSeq Protein accession:NP_002702
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
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GO-P |
GO:0005977;P:glycogen metabolic process;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr30155 |
PHOSPHORYLATION |
48 |
S |
Phospho-ELM |
LTP |
N |
 
|
|
|
HuLPr30155 |
PHOSPHORYLATION |
65 |
S |
Phospho-ELM |
LTP |
N |
|
|
|
HuLPr30155 |
PHOSPHORYLATION |
759 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30155 |
PHOSPHORYLATION |
46 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr30155 |
PHOSPHORYLATION |
65 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30155 |
PHOSPHORYLATION |
759 |
T |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name | |
| Pathway name |
