Protein basic information
| LiverAtlas Protein ID |
HuLPr30237 |
|
Uniprot ID |
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Uniprot Acc |
Q70Z35;Q32KL0;Q32KL1;Q6R7Q3;Q6R7Q4;Q9H805;Q9H961; |
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Protein name |
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein |
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Comment |
FUNCTION:Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase.||SUBUNIT:Interacts with RAC1.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=P-Rex2; IsoId=Q70Z35-1; Sequence=Displayed; Name=2; Synonyms=P-Rexw2A; IsoId=Q70Z35-2; Sequence=VSP 025149, VSP 025151, VSP 025153, VSP 025154, VSP 025155, VSP 025156, VSP 025157, VSP 025158, VSP 025159, VSP 025160, VSP 025161, VSP 025162, VSP 025163; Name=3; IsoId=Q70Z35-3; Sequence=VSP 02515 |
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Gene name |
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 |
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Protein sequence
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MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVG TLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIED ILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRI YDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKN TDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAA VMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWE GSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVY CKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDG TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEW FEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCR QGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEE GVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTF YPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYK SVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHH VLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVV ENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNA EMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRK PLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVG RGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTAC RKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEAG DAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYG VVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKS DEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQ RISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTN CHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKS SEQGKLSPMVYIQHTITTMAAPSG |
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Database cross reference |
RefSeq Protein accession:NP_079146
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005622;C:intracellular;IEA:InterPro. |
|
GO-F |
GO:0005515;F:protein binding;IPI:IntAct. GO:0030675;F:Rac GTPase activator activity;IDA:MGI. GO:0030676;F:Rac guanyl-nucleotide exchange factor activity;IDA:MGI. |
|
GO-P |
GO:0007186;P:G-protein coupled receptor protein signaling pathway;IDA:MGI. GO:0035556;P:intracellular signal transduction;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr30237 |
PHOSPHORYLATION |
1558 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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Pathway
| Pathway name |
