Protein basic information
| LiverAtlas Protein ID |
HuLPr30243 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q86YN6;A2RUM8;A2RUN0;Q86YN3;Q86YN4;Q86YN5;Q8N1N9;Q8TDE4;Q8TDE5; |
|
Protein name |
Peroxisome proliferator-activated receptor gamma coactivator 1-beta |
|
Comment |
FUNCTION:Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure.||SUBUNIT:Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR- alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1.||SUBCELLULAR LOCATION:Nucleus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isofor |
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Subcellular localization |
Nucleus. |
|
Gene name |
peroxisome proliferator-activated receptor gamma, coactivator 1 beta |
|
Protein sequence
|
MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFP ELDLSQLDASDFDSATCFGELQWCPENSETEPNQYSPDD SELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDG GDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQ KLLLATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKAD STQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPP CLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRAD PGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLP KACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVL CDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSV EEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQE EEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKL ESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPS LCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALES PCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFG KKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIK HSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSEL LSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGV LQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRS CDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLA SCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDD EEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSS PCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAI GEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRN RRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSY GGLRHFCWPRYTDYDSNSEEALPA |
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Database cross reference |
RefSeq Protein accession:NP_001166169
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0016592;C:mediator complex;IDA:UniProtKB. |
|
GO-F |
GO:0050682;F:AF-2 domain binding;IPI:UniProtKB. GO:0030331;F:estrogen receptor binding;IDA:UniProtKB. GO:0030374;F:ligand-dependent nuclear receptor transcription coactivator activity;IDA:UniProtKB. GO:0000166;F:nucleotide binding;IEA:InterPro. GO:0030 |
|
GO-P |
GO:0030520;P:estrogen receptor signaling pathway;IDA:UniProtKB. GO:0045944;P:positive regulation of transcription from RNA polymerase II promoter;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr30243 |
PHOSPHORYLATION |
524 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr30243 |
PHOSPHORYLATION |
711 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30243 |
PHOSPHORYLATION |
524 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30243 |
PHOSPHORYLATION |
990 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30243 |
PHOSPHORYLATION |
987 |
Y |
PhosphoSitePlus |
LTP |
N |
|
