HuLPr30254

Uniprot ID

PRKDC_HUMAN

Uniprot Acc

P78527;P78528;Q13327;Q13337;Q14175;Q59H99;Q7Z611;Q96SE6;Q9UME3;

Protein name

DNA-dependent protein kinase catalytic subunit

Comment

FUNCTION:Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phos

Subcellular localization

Nucleus.

Gene name

protein kinase, DNA-activated, catalytic polypeptide

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQ ECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFR ECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKD RAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFY GELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENL FRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFT KSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRL FALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAAL SALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNV DSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQR CKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEV YTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALA AKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDH RASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILAD EAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQ TVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFIN LVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLIS GFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSC FALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIE LDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYID RHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSR AAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQML GSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPF REMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSM VMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDV DQVTRQLYEPLVMQLIHWFTNNKK

Database cross reference

RefSeq Protein accession:NP_001075109
RefSeq Protein gi:126032350

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005958;C:DNA-dependent protein kinase-DNA ligase 4 complex;IDA:MGI. GO:0005667;C:transcription factor complex;IDA:BHF-UCL.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0004677;F:DNA-dependent protein kinase activity;IDA:MGI. GO:0008134;F:transcription factor binding;IPI:BHF-UCL.

GO-P

GO:0032869;P:cellular response to insulin stimulus;IMP:BHF-UCL. GO:0006303; Error!!!Go back to the login page