Protein basic information
| LiverAtlas Protein ID |
HuLPr30309 |
|
Uniprot ID |
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Uniprot Acc |
P85299;B1AHG5;O75983;O95695;Q5BIW2;Q5EAJ8;Q5EAJ9;Q5XKJ6;Q96RW1;Q96RW2;Q9HA49;Q9HC46;Q9NSG0;Q9NVX8;Q9NXL1;Q9UH20; |
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Protein name |
Proline-rich protein 5 |
|
Comment |
FUNCTION:Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.||SUBUNIT:Part of the mammalian target of rapamycin compl |
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Gene name |
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Protein sequence
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MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACAN ATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTEL GSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAET WDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAIT LSVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTED YLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLL RRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAG GTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAP HSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQI LESVDSDSEGIFIDFGRGRGSGMSDLEGSGGRQSVV |
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Database cross reference |
RefSeq Protein accession:NP_001017528
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
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GO-P |
GO:0007049;P:cell cycle;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr30309 |
PHOSPHORYLATION |
11 |
S |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr30309 |
PHOSPHORYLATION |
252 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr30309 |
PHOSPHORYLATION |
254 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr30309 |
PHOSPHORYLATION |
257 |
T |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name |
