Protein basic information
| LiverAtlas Protein ID |
HuLPr30409 |
|
Uniprot ID |
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Uniprot Acc |
Q14997;Q1XBG4;Q1XBG5;Q1XBG6;Q2M1Z0;Q6IPR2;Q86XF8; |
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Protein name |
Proteasome activator complex subunit 4 |
|
Comment |
FUNCTION:Activates proteasomal cleavage of peptides in an energy- independent manner. May be involved in spermatogenesis. May be involved in DNA repair.||SUBUNIT:Homodimer. Interacts with the 20S and 26S proteasomes.||SUBCELLULAR LOCATION:Nucleus. Nucleus speckle. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q14997-1; Sequence=Displayed; Name=2; IsoId=Q14997-2; Sequence=VSP 023878; Name=3; IsoId=Q14997-3; Sequence=VSP 023877, VSP 023879; Name=4; IsoId=Q14997-4; Sequence=VSP 023876; Note=No experimental confirmation available;||SIMILARITY:Contains 6 HEAT repeats.||SEQUENCE CAUTION:Sequence=AAI12170.1; Type=Erroneous initiation; Sequence=AAI13669.1; Type=Erroneous initiation; |
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Subcellular localization |
Nucleus.Nucleus speckle. |
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Gene name |
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Protein sequence
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MEPAERAGVGEPPEPGGRPEPGPRGFVPQKEIVYNKLLPY AERLDAESDLQLAQIKCNLGRAVQLQELWPGGLFWTRKL STYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQG FARLLINLLKKKELLSRADLELPWRPLYDMVERILYSKT EHLGLNWFPNSVENILKTLVKSCRPYFPADATAEMLEEW RPLMCPFDVTMQKAITYFEIFLPTSLPPELHHKGFKLWF DELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDP YVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVI WITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNK LMKLLQRLPNSVVRRLHRERYKKPSWLTPVPDSHKLTDQ DVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPE LVIPPVLERTYPALETLTEPHQLTATLSCVIGVARSLVS GGRWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIA TFSTLVPLVDCSSVLQERNDLTEVERELCSATAEFEDFV LQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGL SSTFSTILTQCSKEIFMVALQKVFNFSTSHIFETRVAGR MVADMCRAAVKCCPEESLKLFVPHCCSVITQLTMNDDVL NDEELDKELLWNLQLLSEITRVDGRKLLLYREQLVKILQ RTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGG FDKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAF YLLDSFLQPELVKLQHCGDGKLEMSRDDILQSLTIVHNC LIGSGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEYDL SRENHREVIATVIRKLLNHILDNSEDDTKSLFLIIKIIG DLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIR ALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLST SSYSQVRNKAQQTFFAALGAYNFC |
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Database cross reference |
RefSeq Protein accession:NP_055429
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016607;C:nuclear speck;IEA:UniProtKB-SubCell. GO:0000502;C:proteasome complex;IEA:UniProtKB-KW. |
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GO-F |
GO:0005488;F:binding;IEA:InterPro. |
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GO-P |
GO:0031145;P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;EXP:Reactome. GO:0006915;P:apoptosis;TAS:Reactome. GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0006977;P:DNA damage response, signal t |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr30409 |
PHOSPHORYLATION |
1121 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr30409 |
PHOSPHORYLATION |
642 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr30409 |
PHOSPHORYLATION |
1746 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30409 |
PHOSPHORYLATION |
1489 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30409 |
PHOSPHORYLATION |
1121 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr30409 |
ACETYLATION |
1397 |
K |
PhosphoSitePlus |
LTP |
N |
|
