Protein basic information
| LiverAtlas Protein ID |
HuLPr30411 |
|
Uniprot ID |
|
|
Uniprot Acc |
O95456;B5BUN2;Q6FHA3;Q6FHD3;Q6S713; |
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Protein name |
Proteasome assembly chaperone 1 |
|
Comment |
FUNCTION:Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.||SUBUNIT:Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.||SUBCELLULAR LOCATION:Cytoplasm. Endoplasmic reticulum.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95456-1; Sequence=Displayed; Name=2; IsoId=O95456-2; Sequence=VSP 017261;||TISSUE SPECIFICITY:In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines.||PTM:Degraded by the proteasome upon completion of 20S proteasome maturation.||SIMILARITY:Belongs to the PSMG1 family. |
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Subcellular localization |
Cytoplasm.Endoplasmic reticulum. |
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Gene name |
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Protein sequence
|
MAATFFGEVVKAPCRAGTEDEEEEEEGRRETPEDREVRLQ LARKREVRLLRRQTKTSLEVSLLEKYPCSKFIIAIGNNA VAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTE AFCVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSC PRKNMQITILTCRHVTDYKTSESTGSLPSPFLRALKTQN FKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLC YTDVMKLDLITVEAFKPILSTRSLKGLVKNIPQSTEILK KLMTTNEIQSNIYT |
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Database cross reference |
RefSeq Protein accession:NP_003711
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005783;C:endoplasmic reticulum;IDA:UniProtKB. |
|
GO-F |
GO:0005515;F:protein binding;IPI:UniProtKB. |
|
GO-P |
GO:0043248;P:proteasome assembly;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr30411 |
PHOSPHORYLATION |
54 |
T |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr30411 |
PHOSPHORYLATION |
4 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30411 |
ACETYLATION |
264 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30411 |
PHOSPHORYLATION |
18 |
T |
PhosphoSitePlus |
LTP |
N |
|
