Protein basic information
| LiverAtlas Protein ID |
HuLPr30421 |
|
Uniprot ID |
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|
Uniprot Acc |
Q6PGN9;Q5T2Z3;Q6ZTI8;Q71MG3;Q9BV77; |
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Protein name |
Proline/serine-rich coiled-coil protein 1 |
|
Comment |
FUNCTION:Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.||SUBUNIT:Interacts with APC2 (By similarity). Interacts with KIF2A.||SUBCELLULAR LOCATION:Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=C; IsoId=Q6PGN9-1; Sequence=Displayed; Name=A; IsoId=Q6PGN9-2; Sequence=VSP 022591; Name=B; IsoId=Q6PGN9-3; Sequenc |
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Subcellular localization |
Cytoplasm.Cytoplasm, cytoskeleton, spindle.Cytoplasm, cytoskeleton, spindle pole. |
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Gene name |
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Protein sequence
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MEDLEEDVRFIVDETLDFGGLSPSDSREEEDITVLVTPEK PLRRGLSHRSDPNAVAPAPQGVRLSLGPLSPEKLEEILD EANRLAAQLEQCALQDRESAGEGLGPRRVKPSPRRETFV LKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSV RALRATSGKRPSNMKRESPTCNLFPASKSPASSPLTRST PPVRGRAGPSGRAAASEETRAAKLRVSGSGEFVGLTLKF LHPSPPGPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSS SQLPIPSAIPRPASRMPLTSRSVPPGRGALPPDSLSTRK GLPRPSTAGHRVRESGHKVPVSQRLNLPVMGATRSNLQP PRKVAVPGPTR |
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Database cross reference |
RefSeq Protein accession:NP_001005290
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;IDA:UniProtKB. GO:0030496;C:midbody;ISS:BHF-UCL. GO:0000922;C:spindle pole;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0008017;F:microtubule binding;ISS:BHF-UCL. |
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GO-P |
GO:0051301;P:cell division;IEA:UniProtKB-KW. GO:0001578;P:microtubule bundle formation;ISS:BHF-UCL. GO:0007080;P:mitotic metaphase plate congression;IDA:UniProtKB. GO:0030308;P:negative regulation of cell growth;ISS:BHF-UCL. GO:0043193;P:positive regul |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr30421 |
PHOSPHORYLATION |
122 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
137 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
140 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
142 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
145 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
175 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
177 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
186 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
190 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
193 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
212 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
245 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
70 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
70 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
98 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
140 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
142 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
175 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
186 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
190 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
145 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
122 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr30421 |
PHOSPHORYLATION |
65 |
S |
PhosphoSitePlus |
HTP |
N |
|
