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Protein basic information

LiverAtlas Protein ID

HuLPr30422

Uniprot ID

PSTK_HUMAN

Uniprot Acc

Q8IV42;Q6ZSS9;

Protein name

L-seryl-tRNA(Sec) kinase

Comment

FUNCTION:Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity).||CATALYTIC ACTIVITY:ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L- seryl-tRNA(Sec).||COFACTOR:Magnesium (By similarity).||PATHWAY:Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route):step 1/2.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IV42-1; Sequence=Displayed; Name=2; IsoId=Q8IV42-2; Sequence=VSP 014989;||SIMILARITY:Belongs to the L-seryl-tRNA(Sec) kinase family.

Gene name

phosphoseryl-tRNA kinase

Protein sequence

MKTAENIRGTGSDGPRKRGLCVLCGLPAAGKSTFARALAH RLQQEQGWAIGVVAYDDVMPDAFLAGARARPAPSQWKLL RQELLKYLEYFLMAVINGCQMSVPPNRTEAMWEDFITCL KDQDLIFSAAFEAQSCYLLTKTAVSRPLFLVLDDNFYYQ SMRYEVYQLARKYSLGFCQLFLDCPLETCLQRNGQRPQA LPPETIHLMGRKLEKPNPEKNAWEHNSLTIPSPACASEA SLEVTDLLLTALENPVKYAEDNMEQKDTDRIICSTNILH KTDQTLRRIVSQTMKEAKGNQEAFSEMTFKQRWVRANHA AIWRIILGNEHIKCRSAKVGWLQCCRIEKRPLSTG

Database cross reference

RefSeq Protein accession:NP_699167
RefSeq Protein gi:224465209

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0016301;F:kinase activity;IEA:UniProtKB-KW.