Protein basic information
| LiverAtlas Protein ID |
HuLPr30477 |
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Uniprot ID |
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Uniprot Acc |
Q8WUK0;Q7Z557;Q96CR2;Q9BXV8; |
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Protein name |
Protein-tyrosine phosphatase mitochondrial 1 |
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Comment |
FUNCTION:Protein phosphatase that specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).||CATALYTIC ACTIVITY:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.||CATALYTIC ACTIVITY:A phosphoprotein + H(2)O = a protein + phosphate.||SUBCELLULAR LOCATION:Mitochondrion inner membrane (By similarity). Note=Associated with the inner membrane (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WUK0-1; Sequence=Displayed; Name=2; IsoId=Q8WUK0-2; Sequence=VSP 015009;||SIMILARITY:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.||SIMILARITY:Contains 1 tyrosine-protein phosphatase domain.||CA |
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Subcellular localization |
Mitochondrion inner membrane(By similarity). |
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Gene name |
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Protein sequence
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MAATALLEAGLARVLFYPTLLYTLFRGKVPGRAHRDWYHR IDPTVLLGALPLRSLTRQLVQDENVRGVITMNEEYETRF LCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFA LKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEE AVRAIAKIRSYIHIRPGQLDVLKEFHKQITARATKDGTF VISKT |
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Database cross reference |
RefSeq Protein accession:NP_001137456
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005743;C:mitochondrial inner membrane;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0004439;F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;ISS:RefGenome. GO:0004725;F:protein tyrosine phosphatase activity;IEA:EC. GO:0008138;F:protein tyrosine/serine/threonine phosphatase activity;ISS:RefGenome. |
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GO-P |
GO:0046855;P:inositol phosphate dephosphorylation;ISS:RefGenome. |
Pathway
| Pathway name |
