HuLPr30544

Uniprot ID

PXDNL_HUMAN

Uniprot Acc

A1KZ92;B5ME43;B6CGZ3;Q6ZMR2;Q96LH9;

Protein name

Peroxidasin-like protein

Comment

CATALYTIC ACTIVITY:2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.||COFACTOR:Binds 1 calcium ion per subunit (By similarity).||COFACTOR:Binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit (By similarity).||SUBCELLULAR LOCATION:Secreted (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A1KZ92-1; Sequence=Displayed; Name=2; IsoId=A1KZ92-2; Sequence=VSP 033070, VSP 033071; Note=No experimental confirmation available;||SIMILARITY:Belongs to the peroxidase family. XPO subfamily.||SIMILARITY:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.||SIMILARITY:Contains 5 LRR (leucine-rich) repeats.||SIMILARITY:Contains 1 LRRCT domain.||SIMILARITY:Contains 1 LRRNT domain.||SIMILARITY:Contains 1 VWFC domain.||SEQUENCE CAUTION:Sequence=AAX70929.1; Type=Frameshift; Positions=127, 132; Sequence=BAB71713.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD18663.1; Type=Erroneo

Subcellular localization

Secreted(Potential).

Gene name

peroxidasin homolog (Drosophila)-like

Protein sequence

MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHL MLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTL LLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTF KGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNK LSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQ GFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPR ITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSL DLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGE AKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECM ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR DHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVV LEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLS SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPK ALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKE GVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSF GLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAI NSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEI FEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLI ANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTW GAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPR LVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPA LSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPC MLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSN VYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFS TGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFR EHNRMATELSALNPHWEGNTVYQE

Database cross reference

RefSeq Protein accession:NP_653252
RefSeq Protein gi:126517478

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005615;C:extracellular space;ISS:UniProtKB.

GO-F

GO:0020037;F:heme binding;ISS:UniProtKB. GO:0004601;F:peroxidase activity;ISS:UniProtKB.

GO-P

GO:0042744;P:hydrogen peroxide catabolic process;ISS:UniProtKB. GO:0055114;P:oxidation-reduction process;ISS:UniProtKB.