HuLPr30552

Uniprot ID

PYGB_HUMAN

Uniprot Acc

P11216;Q96AK1;Q9NPX8;

Protein name

Glycogen phosphorylase, brain form

Comment

FUNCTION:Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.||CATALYTIC ACTIVITY:(1,4-alpha-D-glucosyl)(n) + phosphate = (1,4- alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.||COFACTOR:Pyridoxal phosphate.||ENZYME REGULATION:Activity of phosphorylase is controlled both by allosteric means (through the non-covalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B.||SUBUNIT:Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.||PTM:Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.||SIMILARITY:Belongs to the glycogen phosphorylase family.

Gene name

phosphorylase, glycogen; brain

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTL VKDRNVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERD PKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGL DLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYG YGIRYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPE YMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYK NNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAE NISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFK SSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMR ILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVS MFEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMS VIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVF KDFYELEPEKFQNKTNGITPRRWLLLCNPGLADTIVEKI GEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQENKLKFS AFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVT LYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLVT SIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLS QQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEE AGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQA VDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAY MQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITE YAREIWGVEPSDLQIPPPNIPRD

Database cross reference

RefSeq Protein accession:NP_002853
RefSeq Protein gi:21361370

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Human Fetal Liver;Chinese Liver;French Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IDA:UniProtKB.

GO-F

GO:0008184;F:glycogen phosphorylase activity;NAS:UniProtKB. GO:0030170;F:pyridoxal phosphate binding;IEA:InterPro.

GO-P

GO:0006006;P:glucose metabolic process;TAS:Reactome. GO:0005980;P:glycogen catabolic process;NAS:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr30552

PHOSPHORYLATION

197

Y

Phospho-ELM

21471

HTP

N

HuLPr30552

PHOSPHORYLATION

76

Y

Phospho-ELM

21470

HTP

N

HuLPr30552

PHOSPHORYLATION

15

S

Phospho-ELM

65

HTP

N

HuLPr30552

PHOSPHORYLATION

162

Y

PhosphoSitePlus

18014436

HTP

N

HuLPr30552

PHOSPHORYLATION

562

S

PhosphoSitePlus

18014439

LTP

N

HuLPr30552

ACETYLATION

316

K

PhosphoSitePlus

11318281

LTP

N

HuLPr30552

PHOSPHORYLATION

197

Y

PhosphoSitePlus

460541

LTP

N

HuLPr30552

PHOSPHORYLATION

263

Y

PhosphoSitePlus

15565145

HTP

N

HuLPr30552

ACETYLATION

811

K

PhosphoSitePlus

475749

LTP

N

HuLPr30552

PHOSPHORYLATION

15

S

PhosphoSitePlus

456885

LTP

N

HuLPr30552

PHOSPHORYLATION

186

Y

PhosphoSitePlus

473915

LTP

HTP

N

HuLPr30552

PHOSPHORYLATION

76

Y

PhosphoSitePlus

473916

LTP

N

HuLPr30552

PHOSPHORYLATION

473

Y

PhosphoSitePlus

472936

LTP

N