HuLPr32908

Uniprot ID

Q4GUF2_HUMAN

Uniprot Acc

Q4GUF2;

Protein name

ATP synthase protein 8

Comment

FUNCTION:Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).||SUBUNIT:F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel (By similarity).||SUBCELLULAR LOCATION:Mitochondrion membrane; Single-pass membrane protein (By similarity).||SIMILARITY:Belongs to the ATPase protein 8 family.

Subcellular localization

Mitochondrion membrane;Single-pass membrane protein(By similarity).

Gene name

dynein, axonemal, heavy chain 8

Protein sequence

MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPK PVKMKNYNKPWEPKWTKICSLHSLPPQS

Database cross reference

RefSeq Protein accession:NP_001362
RefSeq Protein gi:126012497

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0000276;C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);IEA:InterPro.

GO-F

GO:0015078;F:hydrogen ion transmembrane transporter activity;IEA:InterPro.

GO-P

GO:0015986;P:ATP synthesis coupled proton transport;IEA:InterPro.