HuLPr33542

Uniprot ID

Q53GA5_HUMAN

Uniprot Acc

Q53GA5;

Protein name

Cellular tumor antigen p53

Comment

FUNCTION:Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).||COFACTOR:Binds 1 zinc ion per subunit (By similarity).||SUBUNIT:Binds DNA as a homotetramer (By similarity).||SUBCELLULAR LOCATION:Cytoplasm. Nucleus (By similarity).||SIMILARITY:Belongs to the p53 family.

Subcellular localization

Cytoplasm.Nucleus(By similarity).

Gene name

tumor protein p53

Protein sequence

YMCNSSCMGGMNGRPILTIITLEDSSGNLLGRNSFEVRVC ACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSS SPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDA QAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

Database cross reference

RefSeq Protein accession:NP_000537
RefSeq Protein gi:120407068

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0010843;F:promoter binding;IEA:InterPro. GO:0003700;F:sequence-specific DNA binding transcription factor activity;IEA:InterPro.

GO-P

GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0007049;P:cell cycle;IEA:UniProtKB-KW. GO:0051262;P:protein tetramerization;IEA:InterPro. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW.

FSH