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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr33757

Uniprot ID

Q53QF9_HUMAN

Uniprot Acc

Q53QF9;

Protein name

Interleukin 1, alpha

Comment

FUNCTION:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).||SUBUNIT:Monomer (By similarity).||SIMILARITY:Belongs to the IL-1 family.

Gene name

interleukin 1, alpha

Protein sequence

MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSY GPLHEGCMDQSVSLSISETSKTSKLTFKESMVVVATNGK VLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSF LSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAAL HNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQ DEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFT SVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA

Database cross reference

RefSeq Protein accession:NP_000566
RefSeq Protein gi:27894330

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IEA:UniProtKB-KW.

GO-F

GO:0005125;F:cytokine activity;IEA:UniProtKB-KW. GO:0005149;F:interleukin-1 receptor binding;IEA:InterPro.

GO-P

GO:0001660;P:fever generation;IEA:UniProtKB-KW. GO:0006955;P:immune response;IEA:InterPro. GO:0051781;P:positive regulation of cell division;IEA:UniProtKB-KW.

Pathway

Pathway name

TCR

Pathway name

IL1

Pathway name

IL5