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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr37276

Uniprot ID

Q6FHF5_HUMAN

Uniprot Acc

Q6FHF5;

Protein name

Proliferating cell nuclear antigen

Comment

FUNCTION:This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity).||SUBCELLULAR LOCATION:Nucleus (By similarity).||SIMILARITY:Belongs to the PCNA family.

Subcellular localization

Nucleus(By similarity).

Gene name

proliferating cell nuclear antigen

Protein sequence

MFEGRLVQGSILKKVLEALKDLINEACWDISSSGVNLQSM DSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKIL KCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKL MDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDA VVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVT IEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPL VVEYKIADMGHLKYNLAPKIEDEEGS

Database cross reference

RefSeq Protein accession:NP_002583
RefSeq Protein gi:4505641

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IDA:HPA. GO:0015630;C:microtubule cytoskeleton;IDA:HPA. GO:0005634;C:nucleus;IDA:HPA. GO:0043626;C:PCNA complex;IEA:InterPro.

GO-F

GO:0003677;F:DNA binding;IEA:HAMAP. GO:0030337;F:DNA polymerase processivity factor activity;IEA:HAMAP.

GO-P

GO:0006260;P:DNA replication;IEA:UniProtKB-KW. GO:0006275;P:regulation of DNA replication;IEA:HAMAP.

Pathway

Pathway name

IL2