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Protein basic information

LiverAtlas Protein ID

HuLPr37350

Uniprot ID

Q6FI30_HUMAN

Uniprot Acc

Q6FI30;

Protein name

Nuclear factor 1

Comment

FUNCTION:Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication (By similarity).||SUBUNIT:Binds DNA as a homodimer (By similarity).||SUBCELLULAR LOCATION:Nucleus (By similarity).||SIMILARITY:Belongs to the CTF/NF-I family.

Subcellular localization

Nucleus(By similarity).

Gene name

nuclear factor I/C (CCAAT-binding transcription factor)

Protein sequence

MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRM SKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPEC REDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKV WRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQP HHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQED SKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTG PNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHK SGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHS GIAQSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHL NPQDPLKDLVSLACDPASQQPGPLNGSGQLKMPSHCLSA QMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSP PDTSPANRSFVGLGPRDPAGIYQAQSWYLG

Database cross reference

RefSeq Protein accession:NP_005588
RefSeq Protein gi:45505149

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0003700;F:sequence-specific DNA binding transcription factor activity;IEA:InterPro.

GO-P

GO:0006260;P:DNA replication;IEA:UniProtKB-KW.

Pathway

Pathway name

IL2