HuLPr37519

Uniprot ID

Q6IB22_HUMAN

Uniprot Acc

Q6IB22;

Protein name

Proteasome subunit beta type

Comment

FUNCTION:The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).||CATALYTIC ACTIVITY:Cleavage of peptide bonds with very broad specificity.||SUBUNIT:The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits (By similarity).||SUBCELLULAR LOCATION:Cytoplasm. Nucleus (By similarity).||SIMILARITY:Belongs to the peptidase T1B family.

Subcellular localization

Cytoplasm.Nucleus(By similarity).

Gene name

proteasome (prosome, macropain) subunit, beta type, 10

Protein sequence

MLKPALEPRGGFSFEKCQRNASLERVLPGLKVPHARKTGT TIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPK IYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATV TRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGS YSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVE AVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPV KRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVD

Database cross reference

RefSeq Protein accession:NP_002792
RefSeq Protein gi:4506191

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. GO:0005839;C:proteasome core complex;IEA:InterPro.

GO-F

GO:0004298;F:threonine-type endopeptidase activity;IEA:UniProtKB-KW.

GO-P

GO:0051603;P:proteolysis involved in cellular protein catabolic process;IEA:InterPro.

TSLP