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Protein basic information

LiverAtlas Protein ID

HuLPr37688

Uniprot ID

Q6IQ28_HUMAN

Uniprot Acc

Q6IQ28;

Protein name

Tyrosine-protein kinase receptor

Comment

CATALYTIC ACTIVITY:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (By similarity).||SIMILARITY:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.||SIMILARITY:Contains 1 protein kinase domain.

Subcellular localization

Membrane;Single-pass type I membrane protein(By similarity).

Gene name

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Protein sequence

MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIH PGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQ NEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLF LVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLP KDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVL SEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTI KDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQAT LTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFI NIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMN RTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYT FLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVA AGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPF GKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAF KGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKY LQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPR NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML KPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGG PTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALY KNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV RIGSYIERDVTPAIMEDDELAIDLEDLLSFSYQVAKGMA FLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND SNYVVKGNARLPVKWMAHESIFNCVYTFESDVWSYGIFL WELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAE MYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYS NLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV

Database cross reference

RefSeq Protein accession:NP_000213
RefSeq Protein gi:4557695

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004714;F:transmembrane receptor protein tyrosine kinase activity;IEA:EC.

GO-P

GO:0006468;P:protein phosphorylation;IEA:InterPro. GO:0007169;P:transmembrane receptor protein tyrosine kinase signaling pathway;IEA:InterPro.

Pathway

Pathway name

IL3

Pathway name

IL4

Pathway name

KitReceptor