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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr39377

Uniprot ID

Q7KZA3_HUMAN

Uniprot Acc

Q7KZA3;

Protein name

Ferrochelatase

Comment

FUNCTION:Catalyzes the ferrous insertion into protoporphyrin IX (By similarity).||CATALYTIC ACTIVITY:Protoheme + 2 H(+) = protoporphyrin + Fe(2+).||PATHWAY:Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX:step 1/1.||SIMILARITY:Belongs to the ferrochelatase family.

Gene name

ferrochelatase

Protein sequence

MAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTT ETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVH DFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRR IGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFR YVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSL NAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHIL KELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVS ATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIK GLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKE CGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQ LTLSCPLCVNPVCRETKSFFTSQQL

Database cross reference

RefSeq Protein accession:NP_000131
RefSeq Protein gi:60499021

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:HAMAP.

GO-F

GO:0051537;F:2 iron, 2 sulfur cluster binding;IEA:UniProtKB-KW. GO:0004325;F:ferrochelatase activity;IEA:HAMAP. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0006783;P:heme biosynthetic process;IEA:HAMAP.