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Protein basic information

LiverAtlas Protein ID

HuLPr39786

Uniprot ID

Q7Z635_HUMAN

Uniprot Acc

Q7Z635;

Protein name

Ephrin receptor

Comment

CATALYTIC ACTIVITY:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (By similarity).||SIMILARITY:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.||SIMILARITY:Contains 1 SAM (sterile alpha motif) domain.||SIMILARITY:Contains 1 protein kinase domain.

Subcellular localization

Membrane;Single-pass type I membrane protein(By similarity).

Gene name

EPH receptor B4

Protein sequence

MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDG QWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVP RRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYES DADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATG KVNVRTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKK CAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSP SLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQG TFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRART DPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGR EDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWV VVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTD REVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEV KYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVR ARSEAGYGPFGQEHHSQTQLDESEGWREQLALIAGTAVV GVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHG TKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGE FGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSE ASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDS FLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLA ARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGK IPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERP YWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQK DRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPL LDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFE LVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGGPAPQY

Database cross reference

RefSeq Protein accession:NP_004435
RefSeq Protein gi:32528301

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005887;C:integral to plasma membrane;IEA:InterPro.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0005003;F:ephrin receptor activity;IEA:InterPro.

GO-P

GO:0006468;P:protein phosphorylation;IEA:InterPro. GO:0007169;P:transmembrane receptor protein tyrosine kinase signaling pathway;IEA:InterPro.