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Protein basic information

LiverAtlas Protein ID

HuLPr43451

Uniprot ID

Q9TGM1_HUMAN

Uniprot Acc

Q9TGM1;

Protein name

NADH-ubiquinone oxidoreductase chain 3

Comment

FUNCTION:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).||CATALYTIC ACTIVITY:NADH + ubiquinone = NAD(+) + ubiquinol.||SUBCELLULAR LOCATION:Mitochondrion membrane; Multi-pass membrane protein (By similarity).||SIMILARITY:Belongs to the complex I subunit 3 family.

Subcellular localization

Mitochondrion membrane;Multi-pass membrane protein(By similarity).

Gene name

acyl-CoA dehydrogenase, long chain

Protein sequence

PWALQTTNLPLMVMSSLLLIIILALSLAYEWLQKGLDWAE

Database cross reference

RefSeq Protein accession:NP_001599
RefSeq Protein gi:4501857

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0031966;C:mitochondrial membrane;IEA:UniProtKB-SubCell. GO:0070469;C:respiratory chain;IEA:UniProtKB-KW.

GO-F

GO:0008137;F:NADH dehydrogenase (ubiquinone) activity;IEA:EC.

GO-P

GO:0022900;P:electron transport chain;IEA:UniProtKB-KW.