Protein basic information
| LiverAtlas Protein ID |
HuLPr44009 |
|
Uniprot ID |
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Uniprot Acc |
Q7Z6M1;O00568;Q69YR2;Q6FHA4;Q6IBG7;Q6P092;Q86Y76;Q9BWB1; |
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Protein name |
Rab9 effector protein with kelch motifs |
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Comment |
FUNCTION:Rab9 effector required for endosome to trans-Golgi network (TGN) transport.||SUBUNIT:Interacts with PIP5K3. Interacts with RAB9 in its GTP- bound conformation.||SUBCELLULAR LOCATION:Cytoplasm. Endosome membrane. Note=Interaction with PIP5K3 and subsequent phosphorylation recruits it to the endosomal membrane.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z6M1-1; Sequence=Displayed; Name=2; IsoId=Q7Z6M1-2; Sequence=VSP 023828;||PTM:Phosphorylated on Ser residues most probably by PIP5K3.||SIMILARITY:Contains 5 Kelch repeats. |
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Subcellular localization |
Cytoplasm.Endosome membrane. |
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Gene name |
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Protein sequence
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MKQLPVLEPGDKPRKATWYTLTVPGDSPCARVGHSCSYLP PVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDT CKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQV LNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG GERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGH VMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNP TGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYH TEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKED SNSLTLNHEAEKEDSADKVMSHSGDSHEESQTATLLCLV FGGMNTEGEIYDDCIVTVVD |
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Database cross reference |
RefSeq Protein accession:NP_001167623
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0010008;C:endosome membrane;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;IDA:HPA. |
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GO-P |
GO:0006898;P:receptor-mediated endocytosis;TAS:ProtInc. GO:0006904;P:vesicle docking involved in exocytosis;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44009 |
PHOSPHORYLATION |
61 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44009 |
PHOSPHORYLATION |
63 |
S |
PhosphoSitePlus |
LTP |
N |
|
