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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr44063

Uniprot ID

RARR2_HUMAN

Uniprot Acc

Q99969;

Protein name

Retinoic acid receptor responder protein 2

Comment

SUBCELLULAR LOCATION:Secreted (Potential).||TISSUE SPECIFICITY:Highly expressed in skin (basal and suprabasal layers of the epidermis, hair follicles and endothelial cells). Also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon.||INDUCTION:Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.

Subcellular localization

Secreted(Potential).

Gene name

retinoic acid receptor responder (tazarotene induced) 2

Protein sequence

MRRLLIPLALWLGAVGVGVAELTEAQRRGLQVALEEFHKH PPVQWAFQETSVESAVDTPFPAGIFVRLEFKLQQTSCRK RDWKKPECKVRPNGRKRKCLACIKLGSEDKVLGRLVHCP IETQVLREAEEHQETQCLRVQRAGEDPHSFYFPGQFAFS KALPRS

Database cross reference

RefSeq Protein accession:NP_002880
RefSeq Protein gi:4506427

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0031012;C:extracellular matrix;IDA:DFLAT.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB.

GO-P

GO:0048566;P:embryonic digestive tract development;IMP:DFLAT. GO:0001701;P:in utero embryonic development;IEP:DFLAT. GO:0010759;P:positive regulation of macrophage chemotaxis;IMP:DFLAT. GO:0001523;P:retinoid metabolic process;IDA:UniProtKB.