Protein basic information
| LiverAtlas Protein ID |
HuLPr44142 |
|
Uniprot ID |
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|
Uniprot Acc |
Q96LT9;D3DT74;Q5TZ87;Q96FK7;Q96JI8;Q9NSU7;Q9NXX2; |
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Protein name |
RNA-binding protein 40 |
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Comment |
FUNCTION:Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.||SUBUNIT:Component of the U11/U12 snRNPs that are part of the U12- type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.||INTERACTION:P04156:PRNP; NbExp=1; IntAct=EBI-2602807, EBI-977302;||SUBCELLULAR LOCATION:Nucleus.||TISSUE SPECIFICITY:Highly expressed in pancreas and kidney. Detected at lower levels in heart, brain, placenta, lung, liver, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes.||SIMILARITY:Contains 2 RRM (RNA recognition motif) domains.||SEQUENCE CAUTION:Sequence=BAA90885.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA90885.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence; Sequence=BAB47468.1; Type=Erroneous initiat |
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Subcellular localization |
Nucleus. |
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Gene name |
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Protein sequence
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MAAPEQPLAISRGCTSSSSLSPPRGDRTLLVRHLPAELTA EEKEDLLKYFGAQSVRVLSDKGRLKHTAFATFPNEKAAI KALTRLHQLKLLGHTLVVEFAKEQDRVHSPCPTSGSEKK KRSDDPVEDDKEKKELGYLTVENGIAPNHGLTFPLNSCL KYMYPPPSSTILANIVNALASVPKFYVQVLHLMNKMNLP TPFGPITARPPMYEDYMPLHAPLPPTSPQPPEEPPLPDE DEELSSEESEYESTDDEDRQRMNKLMELANLQPKRPKTI KQRHVRKKRKIKDMLNTPLCPSHSSLHPVLLPSDVFDQP QPVGNKRIEFHISTDMPAAFKKDLEKEQNCEEKNHDLPA TEVDASNIGFGKIFPKPNLDITEEIKEDSDEMPSECISR RELEKGRISREEMETLSVFRSYEPGEPNCRIYVKNLAKH VQEKDLKYIFGRYVDFSSETQRIMFDIRLMKEGRMKGQA FIGLPNEKAAAKALKEANGYVLFGKPMVVQFARSARPKQDPKEGKRKC |
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Database cross reference |
RefSeq Protein accession:NP_060089
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Ontology annotation
| GO-C |
GO:0005689;C:U12-type spliceosomal complex;IDA:UniProtKB. |
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GO-F |
GO:0000166;F:nucleotide binding;IEA:InterPro. GO:0005515;F:protein binding;IPI:IntAct. GO:0003723;F:RNA binding;IEA:UniProtKB-KW. |
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GO-P |
GO:0006397;P:mRNA processing;IEA:UniProtKB-KW. GO:0008380;P:RNA splicing;IC:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44142 |
PHOSPHORYLATION |
54 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr44142 |
PHOSPHORYLATION |
108 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44142 |
PHOSPHORYLATION |
374 |
T |
PhosphoSitePlus |
LTP |
N |
|
