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Protein basic information

LiverAtlas Protein ID

HuLPr44209

Uniprot ID

RDH16_HUMAN

Uniprot Acc

O75452;Q9UNV2;

Protein name

Retinol dehydrogenase 16

Comment

FUNCTION:Oxidoreductase with a preference for NAD. Oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction.||ENZYME REGULATION:Inhibited by citral, perillyl alcohol, geraniol, farnesol and geranyl geraniol.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=0.14 uM for androsterone; KM=0.22 uM for androstanediol; KM=0.80 uM for dihydrotestosterone; KM=0.13 uM for NAD; KM=190 uM for NADP;||SUBCELLULAR LOCATION:Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential).||TISSUE SPECIFICITY:Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels

Subcellular localization

Microsome membrane;Single-pass type IV membrane protein.Endoplasmic reticulum membrane;Single-pass type IV membrane protein(Potential).

Gene name

retinol dehydrogenase 16 (all-trans)

Protein sequence

MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSG FGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLET VTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLP TAPNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARG RVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELSY FGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVK EAYGEKFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIA CHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIMYWVSPSPAKAL

Database cross reference

RefSeq Protein accession:NP_003699
RefSeq Protein gi:150247226

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;TAS:ProtInc.

GO-F

GO:0005488;F:binding;IEA:InterPro. GO:0009055;F:electron carrier activity;TAS:UniProtKB. GO:0004745;F:retinol dehydrogenase activity;TAS:ProtInc.

GO-P

GO:0006629;P:lipid metabolic process;TAS:ProtInc. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr44209

ACETYLATION

210

K

PhosphoSitePlus

14320656

LTP

N

Pathway

Pathway name

Retinol_Metabolism