HuLPr44210

Uniprot ID

RDH8_HUMAN

Uniprot Acc

Q9NYR8;Q9H838;

Protein name

Retinol dehydrogenase 8

Comment

FUNCTION:Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).||CATALYTIC ACTIVITY:All-trans-retinol + NADP(+) = all-trans- retinal + NADPH.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Potential).||TISSUE SPECIFICITY:Detected in photoreceptor outer segments in the retina (at protein level).||SIMILARITY:Belongs to the short-chain dehydrogenases/reductases (SDR) family.||SEQUENCE CAUTION:Sequence=BAB14782.1; Type=Frameshift; Positions=26;

Subcellular localization

Membrane;Multi-pass membrane protein(Potential).

Gene name

retinol dehydrogenase 8 (all-trans)

Protein sequence

MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMR DLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSC IQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGA VRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAA SKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKL LAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNP QDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSG SLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR

Database cross reference

RefSeq Protein accession:NP_056540
RefSeq Protein gi:7657478

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:InterPro. GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0005488;F:binding;IEA:InterPro. GO:0004303;F:estradiol 17-beta-dehydrogenase activity;IEA:InterPro. GO:0052650;F:NADP-retinol dehydrogenase activity;IEA:EC. GO:0004745;F:retinol dehydrogenase activity;TAS:ProtInc.

GO-P

GO:0006703;P:estrogen biosynthetic process;IEA:InterPro. GO:0050896;P:response to stimulus;IEA:UniProtKB-KW. GO:0007601;P:visual perception;TAS:ProtInc.

Retinol_Metabolism