Protein basic information
| LiverAtlas Protein ID |
HuLPr44272 |
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Uniprot ID |
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Uniprot Acc |
Q6NUM9;A6NIK3;Q53R95;Q53SA9;Q6UX05;Q8N2H5;Q96FA4;Q9NXE5; |
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Protein name |
All-trans-retinol 13,14-reductase |
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Comment |
FUNCTION:Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).||CATALYTIC ACTIVITY:All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor.||COFACTOR:NAD, NADP, or FAD (By similarity).||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NUM9-1; Sequence=Displayed; Name=2; IsoId=Q6NUM9-2; Sequence=VSP 017410, VSP 017411; Note=No experimental confirmation available;||SIMILARITY:Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.||SEQUENCE CAUTION:Sequence=AAH11418.1; Type=Erroneous initiation; Sequence=BAA91069.1; Ty |
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Subcellular localization |
Endoplasmic reticulum membrane;Peripheral membrane protein(By similarity). |
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Gene name |
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Protein sequence
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MWLPLVLLLAVLLLAVLCKVYLGLFSGSSPNPFSEDVKRP PAPLVTDKEARKKVLKQAFSANQVPEKLDVVVIGSGFGG LAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDT GIHYIGRMEEGSIGRFILDQITEGQLDWAPLSSPFDIMV LEGPNGRKEYPMYSGEKAYIQGLKEKFPQEEAIIDKYIK LVKVVSSGAPHAILLKFLPLPVVQLLDRCGLLTRFSPFL QASTQSLAEVLQQLGASSELQAVLSYIFPTYGVTPNHSA FSMHALLVNHYMKGGFYPRGGSSEIAFHTIPVIQRAGGA VLTKATVQSVLLDSAGKACGVSVKKGHELVNIYCPIVVS NAGLFNTYEHLLPGNARCLPGVKQQLGTVRPGLGMTSVF ICLRGTKEDLHLPSTNYYVYYDTDMDQAMERYVSMPREE AAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYE WFEEWQAELKGKRGSDYETFKNSFVEASMSVVLKLFPQL EGKVESVTAGSPLTNQFYLAAPRGACYGADHDLGRLHPC VMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSA ILKRNLYSDLKNLDSRIRAQKKKN |
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Database cross reference |
RefSeq Protein accession:NP_060220
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Ontology annotation
| GO-C |
GO:0005789;C:endoplasmic reticulum membrane;ISS:HGNC. GO:0005640;C:nuclear outer membrane;ISS:HGNC. |
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GO-F |
GO:0051786;F:all-trans-retinol 13,14-reductase activity;ISS:HGNC. GO:0009055;F:electron carrier activity;IEA:InterPro. |
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GO-P |
GO:0055114;P:oxidation-reduction process;ISS:HGNC. GO:0042572;P:retinol metabolic process;ISS:HGNC. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr44272 |
ACETYLATION |
183 |
K |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
