HuLPr44289

Uniprot ID

RFFL_HUMAN

Uniprot Acc

Q8WZ73;E1P633;Q8NHW0;Q8TBY7;Q96BE6;

Protein name

E3 ubiquitin-protein ligase rififylin

Comment

FUNCTION:Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.||PATHWAY:Protein modification; protein ubiquitination.||SUBUNIT:Binds CASP8 and CASP10.||SUBCELLULAR LOCATION:Cytoplasm. Membrane; Peripheral membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WZ73-1; Sequence=Displayed; Name=2; IsoId=Q8WZ73-2; Sequence=VSP 015752; Name=3; IsoId=Q8WZ73-3; Sequence=VSP 015751, VSP 015752;||TISSUE SPECIFICITY:Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.||PTM:Rapidly degraded after stimulation with TNFSF10, probably by caspases.||PTM:Auto-ubiquitinated (in vitro) (By similarity).||PTM:Palmitoylated (By similarity).||SIMILARITY:Contains 1 FYVE-type zinc finger.||SIMILARITY:Contains 1 RING-type zinc finger.||SIMILARITY:C

Subcellular localization

Cytoplasm.Membrane;Peripheral membrane protein.

Gene name

ring finger and FYVE-like domain containing 1

Protein sequence

MWATCCNWFCLDGQPEEVPPPQGARMQAYSNPGYSSFPSP TGLEPSCKSCGAHFANTARKQTCLDCKKNFCMTCSSQVG NGPRLCLLCQRFRATAFQREELMKMKVKDLRDYLSLHDI STEMCREKEELVLLVLGQQPVISQEDRTRASTLSPDFPE QQAFLTQPHSSMVPPTSPNLPSSSAQATSVPPAQVQENQ QANGHVSQDQEEPVYLESVARVPAEDETQSIDSEDSFVP GRRASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCE KWELMERVTRLYKDQKGLQHLVSGAEDQNGGAVPSGLEE NLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICRQ YVIRAVHVFRS

Database cross reference

RefSeq Protein accession:NP_001017368
RefSeq Protein gi:62865649

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0016020;C:membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0016874;F:ligase activity;IEA:UniProtKB-KW. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0006915;P:apoptosis;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr44289

PHOSPHORYLATION

240

S

Phospho-ELM

37768

HTP

yes

HuLPr44289

PHOSPHORYLATION

245

T

Phospho-ELM

37769

HTP

yes

HuLPr44289

PHOSPHORYLATION

34

Y

Phospho-ELM

20638

HTP

N

HuLPr44289

PHOSPHORYLATION

229

S

Phospho-ELM

6774

HTP

yes

HuLPr44289

PHOSPHORYLATION

149

S

PhosphoSitePlus

5450527

LTP

N

HuLPr44289

PHOSPHORYLATION

34

Y

PhosphoSitePlus

458241

HTP

N

HuLPr44289

PHOSPHORYLATION

150

T

PhosphoSitePlus

472296

LTP

N

HuLPr44289

PHOSPHORYLATION

211

Y

PhosphoSitePlus

475437

LTP

N

HuLPr44289

PHOSPHORYLATION

229

S

PhosphoSitePlus

453582

LTP

HTP

yes

HuLPr44289

PHOSPHORYLATION

226

S

PhosphoSitePlus

468619

LTP

HTP

yes

HuLPr44289

PHOSPHORYLATION

240

S

PhosphoSitePlus

468620

LTP

yes

HuLPr44289

PHOSPHORYLATION

29

Y

PhosphoSitePlus

463671

LTP

N

HuLPr44289

ACETYLATION

105

K

PhosphoSitePlus

466756

HTP

N

HuLPr44289

PHOSPHORYLATION

245

T

PhosphoSitePlus

3208095

HTP

yes

HuLPr44289

PHOSPHORYLATION

242

S

PhosphoSitePlus

4149395

HTP

yes

TNF_receptor_signaling_pathway