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Protein basic information

LiverAtlas Protein ID

HuLPr44298

Uniprot ID

RFOX1_HUMAN

Uniprot Acc

Q9NWB1;Q7Z7I7;Q8TAE3;Q8TAF2;Q8WYB2;Q9NS20;

Protein name

RNA binding protein fox-1 homolog 1

Comment

FUNCTION:RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.||SUBUNIT:Binds to the C-terminus of ATXN2.||INTERACTION:P54259:ATN1; NbExp=1; IntAct=EBI-945906, EBI-945980; P54253:ATXN1; NbExp=1; IntAct=EBI-945906, EBI-930964; Q9Y6R0:NUMBL; NbExp=1; IntAct=EBI-945906, EBI-945925; Q9HAU0:PLEKHA5; NbExp=1; IntAct=EBI-945906, EBI-945934; Q92530:PSMF1; NbExp=1; IntAct=EBI-945906, EBI-945916; Q96PU8:QKI; NbExp=1; IntAct=EBI-945906, EBI-945792; O43251:RBFOX2; NbExp=1; IntAct=EBI-945906, EBI-746056;||SUBCELLULAR LOCATION:Nucleus (By similarity). Cytoplasm (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9NWB1-1; Sequence=Displayed; Name=2; Synonyms=Gamma; IsoId=Q9NWB1-2; Sequence=VSP 030874, VSP 030876; Name=3; Synonyms=1; IsoId=Q9NWB1-3; Sequence=VSP 030875; Name=4; Synonyms=Al

Subcellular localization

Nucleus(By similarity).Cytoplasm(By similarity).

Gene name

RNA binding protein, fox-1 homolog (C. elegans) 1

Protein sequence

MNCEREQLRGNQEAAAAPDTMAQPYASAQFAPPQNGIPAE YTAPHPHPAPEYTGQTTVPEHTLNLYPPAQTHSEQSPAD TSAQTVSGTATQTDDAAPTDGQPQTQPSENTENKSQPKR LHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKG FGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVM TNKKTVNPYTNGWKLNPVVGAVYSPEFYAGTVLLCQANQ EGSSMYSAPSSLVYTSAMPGFPYPAATAAAAYRGAHLRG RGRTVYNTFRAAAPPPPIPAYGGVVYQDGFYGADIYGGY AAYRYAQPTPATAAAYSDSYGRVYAADPYHHALAPAPTY GVGAMNAFAPLTDAKTRSHADDVGLVLSSLQASIYRGGYNRFAPY

Database cross reference

RefSeq Protein accession:NP_001135805
RefSeq Protein gi:215272410

Ontology annotation

GO-C

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. GO:0005802;C:trans-Golgi network;IDA:UniProtKB.

GO-F

GO:0000166;F:nucleotide binding;IEA:InterPro. GO:0008022;F:protein C-terminus binding;IPI:UniProtKB. GO:0003723;F:RNA binding;NAS:UniProtKB.

GO-P

GO:0006397;P:mRNA processing;IEA:UniProtKB-KW. GO:0008380;P:RNA splicing;IEA:UniProtKB-KW. GO:0050658;P:RNA transport;NAS:UniProtKB.