Protein basic information
| LiverAtlas Protein ID |
HuLPr44328 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9H4X1;Q6NZ48;Q9UL69; |
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Protein name |
Response gene to complement 32 protein |
|
Comment |
FUNCTION:Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition.||SUBUNIT:Interacts with CDK1 and PLK1.||SUBCELLULAR LOCATION:Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H4X1-1; Sequence=Displayed; Name=2; IsoId=Q9H4X1-2; Sequence=VSP 022873;||TISSUE SPECIFICITY:Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells.||INDUCTION:Up-regulated in aorta endothelial cells in response to complement activation. |
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Subcellular localization |
Cytoplasm.Nucleus.Cytoplasm, cytoskeleton, centrosome. |
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Gene name |
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Protein sequence
|
MKPPAAQGSPAAAAAAAPALDSAAAEDLSDALCEFDAVLA DFASPFHERHFHYEEHLERMKRRSSASVSDSSGFSDSES ADSLYRNSFSFSDEKLNSPTDSTPALLSATVTPQKAKLG DTKELEAFIADLDKTLASM |
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Database cross reference |
RefSeq Protein accession:NP_054778
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Ontology annotation
| GO-C |
GO:0005815;C:microtubule organizing center;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
|
GO-P |
GO:0007049;P:cell cycle;IEA:UniProtKB-KW. GO:0000079;P:regulation of cyclin-dependent protein kinase activity;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44328 |
PHOSPHORYLATION |
29 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr44328 |
PHOSPHORYLATION |
44 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr44328 |
PHOSPHORYLATION |
9 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr44328 |
PHOSPHORYLATION |
65 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44328 |
PHOSPHORYLATION |
111 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44328 |
PHOSPHORYLATION |
77 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44328 |
PHOSPHORYLATION |
97 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44328 |
PHOSPHORYLATION |
69 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44328 |
PHOSPHORYLATION |
71 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44328 |
PHOSPHORYLATION |
75 |
S |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name |
