Protein basic information
| LiverAtlas Protein ID |
HuLPr44338 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q15493;A4FTW1;A8K271;Q53FC9;Q5JRR5; |
|
Protein name |
Regucalcin |
|
Comment |
FUNCTION:Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).||CATALYTIC ACTIVITY:D-glucono-1,5-lactone + H(2)O = D-gluconate.||COFACTOR:Binds 1 divalent metal cation per subunit. Most active with zinc and manganese ions. The physiological cofactor is most likely calcium or magnesium.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=2.7 mM for gluconolactone (with Zn(2+) as cofactor); KM=0.6 mM for gluconolactone (with Mn(2+) as cofactor); KM=1.3 mM for gluconolactone (with Mg(2+) as cofactor); KM=3.7 mM for gluconolactone (with Ca(2+) as cofactor);||SUBCELLULAR LOCATION:Cytoplasm (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15493-1; Sequence=Displayed |
|
Subcellular localization |
Cytoplasm(By similarity). |
|
Gene name |
|
|
Related liver disease name |
|
|
Protein sequence
|
MSSIKIECVLPENCRCGESPVWEEVSNSLLFVDIPAKKVC RWDSFTKQVQRVTMDAPVSSVALRQSGGYVATIGTKFCA LNWKEQSAVVLATVDNDKKNNRFNDGKVDPAGRYFAGTM AEETAPAVLERHQGALYSLFPDHHVKKYFDQVDISNGLD WSLDHKIFYYIDSLSYSVDAFDYDLQTGQISNRRSVYKL EKEEQIPDGMCIDAEGKLWVACYNGGRVIRLDPVTGKRL QTVKLPVDKTTSCCFGGKNYSEMYVTCARDGMDPEGLLR QPEAGGIFKITGLGVKGIAPYSYAG |
|
Database cross reference |
RefSeq Protein accession:NP_004674
|
Liver relevance
|
HCC significant Proteins |
Yes/No |
Yes |
|
Quality score |
|
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;ISS:UniProtKB. GO:0005634;C:nucleus;ISS:UniProtKB. |
|
GO-F |
GO:0005509;F:calcium ion binding;IDA:UniProtKB. GO:0030234;F:enzyme regulator activity;IEA:InterPro. GO:0004341;F:gluconolactonase activity;IDA:UniProtKB. GO:0008270;F:zinc ion binding;IDA:UniProtKB. |
|
GO-P |
GO:0006874;P:cellular calcium ion homeostasis;ISS:UniProtKB. GO:0032781;P:positive regulation of ATPase activity;ISS:UniProtKB. GO:0050848;P:regulation of calcium-mediated signaling;ISS:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44338 |
PHOSPHORYLATION |
172 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44338 |
PHOSPHORYLATION |
60 |
S |
PhosphoSitePlus |
HTP |
N |
|
