HuLPr44339

Uniprot ID

RGNEF_HUMAN

Uniprot Acc

Q8N1W1;Q8NCM7;Q96E37;Q9H6L3;Q9H6W0;

Protein name

Rho-guanine nucleotide exchange factor

Comment

FUNCTION:Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).||SUBUNIT:Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2. Interacts with NEFL (By similarity). Interacts with CTNND2; prevents interaction with RHOA.||SUBCELLULAR LOCATION:Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with the microtubule radial and cortical systems (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8N1W1-1; Sequence=Displayed; Name=2; IsoId=Q8N1W

Subcellular localization

Cytoplasm(By similarity).Cell membrane(By similarity).

Gene name

190 kDa guanine nucleotide exchange factor

Protein sequence

MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSH QRHVMIAERIEDNVLQSSVPGHGLQETVTVSVCLCSEGY SPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTL LTPFALTAGALPALDEELVLALTHLELPLEWTVLGSSSL EVSSHRESLLHLAMRWGLAKLSQFFLCLPGGVQALALPN EEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLS EEASLHYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWD RAFLVKAFEPEARPEERTAMPSSGAETEEEIKNSVSSRS AAEKEDIKRVKSLVVQHNEHEDQHSLDLDRSFDILKKSK PPSTLLAAGRLSDMLNGGDEVYANCMVIDQVGDLDISYI NIEGITATTSPESRGCTLWPQSSKHTLPTETSPSVYPLS ENVEGTAHTEAQQSFMSPSSSCASNLNLSFGWHGFEKEQ SHLKKRSSSLDALDADSEGEGHSEPSHICYTPGSQSSSR TGIPSGDELDSFETNTEPDFNISRAESLPLSSNLQSKES LLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSSEEQRA YSLSEPPRENRIQEEEWDKYIIPAKSESEKYKVSRTFSF LMNRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTFSGVL QCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKF QEKYNKNKPQTILGNSSFRDIPQPGLSLHPSSSVPVGLP TGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDHN SCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLS SDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQ TEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLD ELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQ QFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKFQN FIKLRNSNLLARRRGIPECILLVT

Database cross reference

RefSeq Protein accession:NP_001073948
RefSeq Protein gi:295148073

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0005089;F:Rho guanyl-nucleotide exchange factor activity;IEA:InterPro. GO:0003723;F:RNA binding;IEA:UniProtKB-KW.

GO-P

GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0035556;P:intracellular signal transduction;IEA:InterPro. GO:0035023;P:regulation of Rho protein signal transduction;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr44339

PHOSPHORYLATION

624

S

PhosphoSitePlus

3206034

LTP

N

Signaling_events_mediated_by_focal_adhesion_kinase

Regulation_of_RhoA_activity