Protein basic information
| LiverAtlas Protein ID |
HuLPr44416 |
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Uniprot ID |
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Uniprot Acc |
A7KAX9;O94820;Q86YL6;Q8IUG4;Q9BWG3; |
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Protein name |
Rho GTPase-activating protein 32 |
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Comment |
FUNCTION:GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).||SUBUNIT:Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1. Interacts with SHC3 (via SH2 domain). Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR. Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex |
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Subcellular localization |
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.Cell projection, dendritic spine(By similarity).Cytoplasm, cell cortex.Endosome membrane(By similarity).Golgi apparatus membrane(By similarity).Endoplasmic reticulum membrane(By similarity).Membrane. |
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Gene name |
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Protein sequence
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METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRK MKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGA DVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMA ECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYL VQIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLS ELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPA LTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARA PDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPG HCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKS RPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQS CTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDL TKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLA DYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFM EVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPK SLLVSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVG EGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSWRSFF NLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRS AKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNGE MLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAEDV DLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLD SPGYSKDKPSANKKDAETGSSQCQTPGSTASSEPVSPLQ EKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRK LSKSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSS TWDKCVEERDATNRSPTQIVKMKTNETVAQEAYESEVQP LDQVAAEEVELPGKEDQSVSSSQS |
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Database cross reference |
RefSeq Protein accession:NP_001136157
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005938;C:cell cortex;IEA:UniProtKB-SubCell. GO:0030054;C:cell junction;IEA:UniProtKB-KW. GO:0005829;C:cytosol;TAS:Reactome. GO:0043197;C:dendritic spine;IEA:UniProtKB-SubCell. GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0 |
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GO-F |
GO:0005096;F:GTPase activator activity;TAS:Reactome. GO:0035091;F:phosphatidylinositol binding;IEA:InterPro. |
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GO-P |
GO:0007154;P:cell communication;IEA:InterPro. GO:0051056;P:regulation of small GTPase mediated signal transduction;TAS:Reactome. GO:0007264;P:small GTPase mediated signal transduction;TAS:Reactome. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr44416 |
PHOSPHORYLATION |
2048 |
Y |
PhosphoSitePlus |
HTP |
N |
 
|
|
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HuLPr44416 |
PHOSPHORYLATION |
1632 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44416 |
PHOSPHORYLATION |
1702 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44416 |
PHOSPHORYLATION |
1718 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44416 |
PHOSPHORYLATION |
1537 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44416 |
PHOSPHORYLATION |
1704 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
892 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
2023 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
871 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
1236 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
1557 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr44416 |
PHOSPHORYLATION |
2029 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44416 |
PHOSPHORYLATION |
2031 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44416 |
PHOSPHORYLATION |
1788 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
1203 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
1473 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr44416 |
ACETYLATION |
688 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
1088 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
1700 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
1739 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr44416 |
PHOSPHORYLATION |
2005 |
Y |
PhosphoSitePlus |
HTP |
N |
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HuLPr44416 |
PHOSPHORYLATION |
732 |
S |
PhosphoSitePlus |
HTP |
N |
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Pathway
| Pathway name | |
| Pathway name |
