Protein basic information
| LiverAtlas Protein ID |
HuLPr44481 |
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Uniprot ID |
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Uniprot Acc |
Q7LG56;Q17R22;Q75PQ6;Q75PQ7;Q75PY8;Q75PY9;Q86YE3;Q9NPD6;Q9NTD8;Q9NUW3; |
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Protein name |
Ribonucleoside-diphosphate reductase subunit M2 B |
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Comment |
FUNCTION:Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.||CATALYTIC ACTIVITY:2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.||COFACTOR:Binds 2 iron ions per subunit.||PATHWAY:Genetic information processing; DNA replication.||SUBUNIT:Heterotetramer with large (RRM1) subunit. Interacts with p53/TP53. Interacts with RRM1 in response to DNA damage.||SUBCELLULAR LOCATION:Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q7LG56-1; Sequence=Displayed; Name=2; Synonyms=Lon |
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Subcellular localization |
Cytoplasm.Nucleus. |
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Gene name |
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Protein sequence
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MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSR RFVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWN KLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVP EARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFN AIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGV FFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFA CLMFQYLVNKPSEERVREIIVDAVKIEQEFLTEALPVGL IGMNCILMKQYIEFVADRLLVELGFSKVFQAENPFDFME NISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF |
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Database cross reference |
RefSeq Protein accession:NP_001165948
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Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:HPA. GO:0005654;C:nucleoplasm;TAS:Reactome. |
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GO-F |
GO:0004748;F:ribonucleoside-diphosphate reductase activity;IEA:EC. GO:0046914;F:transition metal ion binding;IEA:InterPro. |
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GO-P |
GO:0009186;P:deoxyribonucleoside diphosphate metabolic process;IEA:InterPro. GO:0006281;P:DNA repair;IEA:UniProtKB-KW. GO:0015949;P:nucleobase, nucleoside and nucleotide interconversion;TAS:Reactome. GO:0055114;P:oxidation-reduction process;IEA:UniProtK |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr44481 |
PHOSPHORYLATION |
72 |
S |
PhosphoSitePlus |
LTP |
N |
 
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Pathway
| Pathway name | |
| Pathway name | |
| Pathway name |
