Protein basic information
| LiverAtlas Protein ID |
HuLPr44646 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9NWF9;Q6Y691;Q75ML7;Q7Z2H7;Q7Z7C1;Q8NHW7;Q9NYT1; |
|
Protein name |
E3 ubiquitin-protein ligase RNF216 |
|
Comment |
FUNCTION:Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.||PATHWAY:Protein modification; protein ubiquitination.||SUBUNIT:Interacts with UBE2L3 and to some extent with UBE2L6. Interacts with TRAF3, TLR3, TLR4, TLR5 and TLR9. Isoform 3/ZIN binds RIPK1 and HIV VIF.||SUBCELLULAR LOCATION:Cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=TRIAD3A; IsoId=Q9NWF9-2; Sequence=Displayed; Name=2; Synonyms=TRIAD3B; IsoId=Q9NWF9-1; Sequence=VSP 012444; Name=3; Synonyms=ZIN, TRIAD3; IsoId=Q9NWF9-3; Sequence=VSP 012443 |
|
Subcellular localization |
Cytoplasm. |
|
Gene name |
|
|
Protein sequence
|
MEEGNNNEEVIHLNNFHCHRGQEWINLRDGPITISDSSDE ERIPMLVTPAPQQHEEEDLDDDVILTEDDSEDDYGEFLD LGPPGISEFTKPSGQTEREPKPGPSHNQAANDIVNPRSE QKVIILEEGSLLYTESDPLETQNQSSEDSETELLSNLGE SAALADDQAIEEDCWLDHPYFQSLNQQPREITNQVVPQE RQPEAELGRLLFQHEFPGPAFPRPEPQQGGISGPSSPQP AHPLGEFEDQQLASDDEEPGPAFPMQESQEPNLENIWGQ EAAEVDQELVELLVKETEARFPDVANGFIEEIIHFKNYY DLNVLCNFLLENPDYPKREDRIIINPSSSLLASQDETKL PKIDFFDYSKLTPLDQRCFIQAADLLMADFKVLSSQDIK WALHELKGHYAITRKALSDAIKKWQELSPETSGKRKKRK QMNQYSYIDFKFEQGDIKIEKRMFFLENKRRHCRSYDRR ALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQK DGQLIECRCCYGEFPFEELTQCADAHLFCKECLIRYAQE AVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYY ERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPN PHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIE EKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLC RVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEK LIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRV EALPRPVPQNLPQPQMPPYAFAHPPFPLPPVRPVFNNFP LNMGPIPAPYVPPLPNVRVNYDFGPIHMPLEHNLPMHFGPQPRHRF |
|
Database cross reference |
RefSeq Protein accession:NP_996994
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:HPA. GO:0005634;C:nucleus;IDA:HPA. GO:0005634;C:nucleus;IDA:LIFEdb. |
|
GO-F |
GO:0016874;F:ligase activity;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:IntAct. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro. |
|
GO-P |
GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW. GO:0043161;P:proteasomal ubiquitin-dependent protein catabolic process;IDA:UniProtKB. GO:0070936;P:protein K48-linked ubiquitination;IDA:U |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44646 |
PHOSPHORYLATION |
387 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44646 |
PHOSPHORYLATION |
401 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44646 |
PHOSPHORYLATION |
719 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44646 |
ACETYLATION |
425 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44646 |
PHOSPHORYLATION |
419 |
S |
PhosphoSitePlus |
LTP |
N |
|
