HuLPr44689

Uniprot ID

RNH2A_HUMAN

Uniprot Acc

O75792;B2RCY1;Q96F11;

Protein name

Ribonuclease H2 subunit A

Comment

FUNCTION:Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.||CATALYTIC ACTIVITY:Endonucleolytic cleavage to 5'- phosphomonoester.||COFACTOR:Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding (By similarity).||SUBUNIT:The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.||SUBCELLULAR LOCATION:Nucleus (Probable).||DISEASE:Defects in RNASEH2A are the cause of Aicardi-Goutieres syndrome type 4 (AGS4) [MIM:610333]. A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcif

Subcellular localization

Nucleus(Probable).

Gene name

ribonuclease H2, subunit A

Protein sequence

MDLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGP VLGPMVYAICYCPLPRLADLEALKVADSKTLLESERERL FAKMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSH DTATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSF PGIEVTVKAKADALYPVVSAASICAKVARDQAVKKWQFV EKLQDLDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVR FSWRTAQTILEKEAEDVIWEDSASENQEGLRKITSYFLN EGSQARPRSSHRYFLERGLESATSL

Database cross reference

RefSeq Protein accession:NP_006388
RefSeq Protein gi:38455391

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. GO:0032299;C:ribonuclease H2 complex;IDA:UniProtKB.

GO-F

GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0004523;F:ribonuclease H activity;IDA:UniProtKB. GO:0003723;F:RNA binding;IEA:InterPro.

GO-P

GO:0006260;P:DNA replication;TAS:UniProtKB. GO:0006401;P:RNA catabolic process;IDA:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr44689

PHOSPHORYLATION

204

T

Phospho-ELM

40823

HTP

N

HuLPr44689

PHOSPHORYLATION

216

T

Phospho-ELM

40824

HTP

N

HuLPr44689

PHOSPHORYLATION

172

Y

PhosphoSitePlus

464185

HTP

N

HuLPr44689

PHOSPHORYLATION

206

Y

PhosphoSitePlus

464186

LTP

N

HuLPr44689

PHOSPHORYLATION

210

Y

PhosphoSitePlus

464187

LTP

HTP

N

HuLPr44689

PHOSPHORYLATION

68

S

PhosphoSitePlus

11537360

LTP

N

HuLPr44689

PHOSPHORYLATION

208

S

PhosphoSitePlus

10943318

LTP

HTP

N

HuLPr44689

PHOSPHORYLATION

204

T

PhosphoSitePlus

3177464

LTP

N

HuLPr44689

PHOSPHORYLATION

216

T

PhosphoSitePlus

3177467

LTP

N