Protein basic information
| LiverAtlas Protein ID |
HuLPr44713 |
|
Uniprot ID |
|
|
Uniprot Acc |
O95758;B1ALY3;Q68DB9;Q86YB3;Q86YH9; |
|
Protein name |
Regulator of differentiation 1 |
|
Comment |
FUNCTION:May play a role in regulation of differentiation. In vitro, binds RNA, preferentially to both poly(G) and poly(U). Overexpressed, blocks differentiation of K562 leukemia cells following treatment with phorbol esters or sodium butyrate without affecting proliferation.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=3; IsoId=O95758-3; Sequence=Displayed; Name=1; IsoId=O95758-1; Sequence=VSP 035985; Name=2; IsoId=O95758-2; Sequence=VSP 035985, VSP 010867, VSP 010868; Name=4; IsoId=O95758-4; Sequence=VSP 035986; Name=5; IsoId=O95758-5; Sequence=VSP 010867;||TISSUE SPECIFICITY:Expressed in several hematopoietic cell lines examined.||SIMILARITY:Contains 4 RRM (RNA recognition motif) domains.||SEQUENCE CAUTION:Sequence=AAH39896.1; Type=Erroneous initiation; Sequence=BAA75466.1; Type=Erroneous initiation; Sequence=BI463123; Type=Frameshift; Positions=92; |
|
Gene name |
|
|
Protein sequence
|
MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTA NGNDSKKFKRDRPPCSPSRVLHLRKIPCDVTEAEIISLG LPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPIT PHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAV QSGSLALSGGPSNEGTVLPGQSPVLRIIIENLFYPVTLE VLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYA KMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFT RLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAP AIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGAS GIPGNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIM FNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLS KHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQN IFPPSATLHLSNIPPSVTVDDLKNLFIEAGCSVKAFKFF QKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI |
|
Database cross reference |
RefSeq Protein accession:NP_001157260
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;IEA:InterPro. |
|
GO-F |
GO:0000166;F:nucleotide binding;IEA:InterPro. GO:0003723;F:RNA binding;TAS:ProtInc. |
|
GO-P |
GO:0009653;P:anatomical structure morphogenesis;TAS:ProtInc. GO:0006397;P:mRNA processing;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44713 |
PHOSPHORYLATION |
127 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr44713 |
PHOSPHORYLATION |
448 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44713 |
PHOSPHORYLATION |
464 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44713 |
ACETYLATION |
257 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44713 |
ACETYLATION |
423 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44713 |
ACETYLATION |
549 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44713 |
ACETYLATION |
510 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44713 |
PHOSPHORYLATION |
454 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44713 |
ACETYLATION |
264 |
K |
PhosphoSitePlus |
HTP |
N |
|
