HuLPr44756

Uniprot ID

RPC3_HUMAN

Uniprot Acc

Q9BUI4;O15317;Q9Y3R6;

Protein name

DNA-directed RNA polymerase III subunit RPC3

Comment

FUNCTION:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.||SUBUNIT:Component of

Subcellular localization

Nucleus(By similarity).

Gene name

polymerase (RNA) III (DNA directed) polypeptide C (62kD)

Protein sequence

MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIA HDTGTSLDQVKKALCVLVQHNLVSYQVHKRGVVEYEAQC SRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTM SAVVKKVADRLTETMEDGKTMDYAEVSNTFVRLADTHFV QRCPSVPTTENSDPGPPPPAPTLVINEKDMYLVPKLSLI GKGKRRRSSDEDAAGEPKAKRPKYTTDNKEPIPDDGIYW QANLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMS EITTSSSAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLT LLADDPLEFVGKSGDSGGGMYVINLHKALASLATATLES VVQERFGSRCARIFRLVLQKKHIEQKQVEDFAMIPAKEA KDMLYKMLSENFMSLQEIPKTPDHAPSRTFYLYTVNILS AARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEA IIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNK LDASEIQVDETIFLLESYIECTMKRQ

Database cross reference

RefSeq Protein accession:NP_006459
RefSeq Protein gi:21359969

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005666;C:DNA-directed RNA polymerase III complex;TAS:ProtInc.

GO-F

GO:0003677;F:DNA binding;IEA:InterPro. GO:0003899;F:DNA-directed RNA polymerase activity;TAS:ProtInc.

GO-P

GO:0045087;P:innate immune response;IEA:UniProtKB-KW. GO:0045089;P:positive regulation of innate immune response;IMP:UniProtKB. GO:0032728;P:positive regulation of interferon-beta production;IMP:UniProtKB. GO:0006359;P:regulation of transcription from R

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr44756

PHOSPHORYLATION

194

S

Phospho-ELM

42102

HTP

N

HuLPr44756

PHOSPHORYLATION

412

T

Phospho-ELM

42103

HTP

N

HuLPr44756

PHOSPHORYLATION

194

S

PhosphoSitePlus

3210978

LTP

N

HuLPr44756

PHOSPHORYLATION

412

T

PhosphoSitePlus

3210981

LTP

N

Pyrimidine_Metabolism