Protein basic information
| LiverAtlas Protein ID |
HuLPr44760 |
|
Uniprot ID |
|
|
Uniprot Acc |
O15318;A8MTH0; |
|
Protein name |
DNA-directed RNA polymerase III subunit RPC7 |
|
Comment |
FUNCTION:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F- RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through |
|
Subcellular localization |
Nucleus(By similarity). |
|
Gene name |
|
|
Protein sequence
|
MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPD TDYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPE ERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKK AGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKS DEENEEKEGSKEKSKEGDDDDDDDAAEQEEYDEEEQEEE NDYINSYFEDGDDFGADSDDNMDEATY |
|
Database cross reference |
RefSeq Protein accession:NP_006458
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Ontology annotation
| GO-C |
GO:0005666;C:DNA-directed RNA polymerase III complex;TAS:ProtInc. |
|
GO-F |
GO:0003899;F:DNA-directed RNA polymerase activity;TAS:ProtInc. |
|
GO-P |
GO:0045087;P:innate immune response;IEA:UniProtKB-KW. GO:0045089;P:positive regulation of innate immune response;IMP:UniProtKB. GO:0032728;P:positive regulation of interferon-beta production;IMP:UniProtKB. GO:0006359;P:regulation of transcription from R |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44760 |
PHOSPHORYLATION |
133 |
T |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr44760 |
PHOSPHORYLATION |
157 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr44760 |
PHOSPHORYLATION |
133 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44760 |
ACETYLATION |
89 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44760 |
PHOSPHORYLATION |
157 |
S |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name |
