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Protein basic information

LiverAtlas Protein ID

HuLPr44775

Uniprot ID

RPGFL_HUMAN

Uniprot Acc

Q9UHV5;

Protein name

Rap guanine nucleotide exchange factor-like 1

Comment

FUNCTION:Probable guanine nucleotide exchange factor (GEF).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UHV5-1; Sequence=Displayed; Name=2; IsoId=Q9UHV5-2; Sequence=VSP 035217; Name=3; IsoId=Q9UHV5-3; Sequence=VSP 035385, VSP 035386;||SIMILARITY:Contains 1 Ras-GEF domain.||SEQUENCE CAUTION:Sequence=BAG36274.1; Type=Erroneous initiation;

Gene name

Rap guanine nucleotide exchange factor (GEF)-like 1

Protein sequence

MKPLEKFLKKQTSQLAGRTVAGGPGGGLGSCGGPGGGGGP GGGGGPAGGQRSLQRRQSVSRLLLPAFLREPPAEPGLEP PVPEEGGEPAGVAEEPGSGGPCWLQLEEVPGPGPLGGGG PLRSPSSYSSDELSPGEPLTSPPWAPLGAPERPEHLLNR VLERLAGGATRDSAASDILLDDIVLTHSLFLPTEKFLQE LHQYFVRAGGMEGPEGLGRKQACLAMLLHFLDTYQGLLQ EEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLVET VELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGS DEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYS EEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINS HLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVAN HLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLL QRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQ NQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRK FENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFL HEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDM EASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ

Database cross reference

RefSeq Protein accession:NP_057423
RefSeq Protein gi:7705939

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005622;C:intracellular;IEA:InterPro. GO:0005624;C:membrane fraction;TAS:ProtInc.

GO-F

GO:0005085;F:guanyl-nucleotide exchange factor activity;TAS:ProtInc.

GO-P

GO:0007186;P:G-protein coupled receptor protein signaling pathway;TAS:ProtInc. GO:0007399;P:nervous system development;TAS:ProtInc. GO:0007264;P:small GTPase mediated signal transduction;IEA:InterPro.