Protein basic information
| LiverAtlas Protein ID |
HuLPr44800 |
|
Uniprot ID |
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|
Uniprot Acc |
Q5VZM2;A8K042;Q15348;Q8N3T0; |
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Protein name |
Ras-related GTP-binding protein B |
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Comment |
FUNCTION:Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway.||SUBUNIT:The short isoform binds GTP (By similarity). Interacts with RRAGC and RRAGD.||INTERACTION:Q9HB90:RRAGC; NbExp=1; IntAct=EBI-993049, EBI-752390; Q9NQL2:RRAGD; NbExp=1; IntAct=EBI-993049, EBI-992949;||SUBCELLULAR LOCATION:Cytoplasm. Lysosome.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q5VZM2-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q5VZM2-2; Sequence=VSP 052073;||SIMILARITY:Belongs to the GTR/RAG GTP-binding protein family. |
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Subcellular localization |
Cytoplasm.Lysosome. |
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Gene name |
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Protein sequence
|
MEESDSEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMK KKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDR IHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLV LNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVES RELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQED QRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWS SIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLV ISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSM EVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIR NARKHFEKLERVDGPKQCLLMR |
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Database cross reference |
RefSeq Protein accession:NP_006055
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005794;C:Golgi apparatus;IDA:HPA. GO:0005764;C:lysosome;IDA:UniProtKB. GO:0005634;C:nucleus;IEA:InterPro. |
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GO-F |
GO:0005525;F:GTP binding;IDA:HGNC. GO:0005515;F:protein binding;IPI:UniProtKB. |
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GO-P |
GO:0034613;P:cellular protein localization;IMP:UniProtKB. GO:0071230;P:cellular response to amino acid stimulus;IMP:UniProtKB. GO:0032008;P:positive regulation of TOR signaling cascade;NAS:UniProtKB. GO:0007165;P:signal transduction;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44800 |
PHOSPHORYLATION |
58 |
S |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr44800 |
PHOSPHORYLATION |
64 |
Y |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name |
