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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr44859

Uniprot ID

RSAD2_HUMAN

Uniprot Acc

Q8WXG1;Q8WVI4;

Protein name

Radical S-adenosyl methionine domain-containing protein 2

Comment

FUNCTION:Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus.||COFACTOR:Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).||SUBUNIT:Interacts with FPPS.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Note=Probably associates with the cytosolic side of the endoplasmic reticulum. Infection with human cytomegalovirus (HCMV) causes relocation to

Subcellular localization

Endoplasmic reticulum membrane;Peripheral membrane protein;Cytoplasmic side.Golgi apparatus.

Gene name

radical S-adenosyl methionine domain containing 2

Protein sequence

MWVLTPAAFAGKLLSVFRQPLSSLWRSLVPLFCWLRATFW LLATKRRKQQLVLRGPDETKEEEEDPPLPTTPTSVNYHF TRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKEAGME KINFSGGEPFLQDRGEYLGKLVRFCKVELRLPSVSIVSN GSLIRERWFQNYGEYLDILAISCDSFDEEVNVLIGRGQG KKNHVENLQKLRRWCRDYRVAFKINSVINRFNVEEDMTE QIKALNPVRWKVFQCLLIEGENCGEDALREAERFVIGDE EFERFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNC RKGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYIW SKADLKLDW

Database cross reference

RefSeq Protein accession:NP_542388
RefSeq Protein gi:19923667

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0005794;C:Golgi apparatus;IEA:UniProtKB-SubCell.

GO-F

GO:0003824;F:catalytic activity;IEA:InterPro. GO:0051536;F:iron-sulfur cluster binding;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0051607;P:defense response to virus;IDA:UniProtKB.

Pathway

Pathway name

IL4