Protein basic information
| LiverAtlas Protein ID |
HuLPr44875 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9BXY4;B2RC27;Q5VTV4;Q96K87; |
|
Protein name |
R-spondin-3 |
|
Comment |
FUNCTION:Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (By similarity).||SUBUNIT:Interacts with the extracelular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity).||SUBCELLULAR LOCATION:Secreted (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BXY4-1; Sequence=Displayed; Name=2; IsoId=Q9BXY4-2; Sequence=VSP 018324; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and |
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Subcellular localization |
Secreted(By similarity). |
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Gene name |
|
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Protein sequence
|
MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQG CQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSS CPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGF YLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWS PCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNET RKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDS KSLESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH |
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Database cross reference |
RefSeq Protein accession:NP_116173
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0008201;F:heparin binding;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44875 |
PHOSPHORYLATION |
241 |
S |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr44875 |
PHOSPHORYLATION |
240 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44875 |
PHOSPHORYLATION |
237 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr44875 |
PHOSPHORYLATION |
235 |
S |
PhosphoSitePlus |
LTP |
N |
|
