Protein basic information
| LiverAtlas Protein ID |
HuLPr44915 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9Y3I0;B2R6A8;Q6IAI0;Q9BWL4;Q9NTH1;Q9P037;Q9P0J3; |
|
Protein name |
tRNA-splicing ligase RtcB homolog |
|
Comment |
FUNCTION:Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs.||CATALYTIC ACTIVITY:ATP + (ribonucleotide)(n) + (ribonucleotide)(m) = AMP + diphosphate + (ribonucleotide)(n+m).||SUBUNIT:Catalytic component of the tRNA-splicing ligase complex.||SUBCELLULAR LOCATION:Cytoplasm (By similarity).||SIMILARITY:Belongs to the RtcB family.||SEQUENCE CAUTION:Sequence=AAF29081.1; Type=Frameshift; Positions=295, 298; Sequence=AAF67477.1; Type=Frameshift; Positions=173, 180; |
|
Subcellular localization |
Cytoplasm(By similarity). |
|
Gene name |
|
|
Protein sequence
|
MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVND ALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIV HRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGF DINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGS KGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEY GRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVD EIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDAL VAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAA GNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVS HNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVD YQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGA GRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVME EAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG |
|
Database cross reference |
RefSeq Protein accession:NP_055121
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Fetal Liver;Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0072669;C:tRNA-splicing ligase complex;IDA:UniProtKB. |
|
GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0003972;F:RNA ligase (ATP) activity;IDA:UniProtKB. GO:0017166;F:vinculin binding;IPI:UniProtKB. |
|
GO-P |
GO:0007160;P:cell-matrix adhesion;NAS:UniProtKB. GO:0034446;P:substrate adhesion-dependent cell spreading;NAS:UniProtKB. GO:0006388;P:tRNA splicing, via endonucleolytic cleavage and ligation;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44915 |
PHOSPHORYLATION |
439 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr44915 |
PHOSPHORYLATION |
439 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44915 |
ACETYLATION |
496 |
K |
PhosphoSitePlus |
LTP |
N |
|
